Safety Aspects of 36 Months of Administration of Long-acting Intramuscular Testosterone Undecanoate for Treatment of Female-to-Male Transgender Individuals

Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals.


Endokrinologikum Hamburg, Center for Hormonal and Metabolic Diseases, Reproductive Endocrinology, Lornsenstrasse 4-6, Hamburg 22767, Germany.



Testosterone treatment is essential for the induction and maintenance of virilization of female-to-male (FTM) transsexuals. Aim To test the safety of a novel testosterone preparation for this purpose.


Parenteral long-acting testosterone undecanoate (TU) was administered to 17 FTM transsexuals over 36 months. Observations were made while subjects received treatment.


Serum testosterone rose from 0.50+/-0.25 to 6.2+/-1.3 ng/ml at 6 months and remained stable thereafter. The testosterone profiles were largely identical with those in hypogonadal receiving TU. There were no side effects. Over the 36 months of the study, there was a small but significant decrease in plasma cholesterol (from 218+/-47 to 188+/-42 mg/dl) and low-density lipoprotein-cholesterol (from 139+/-48 to 139+/-48 mg/dl), while plasma levels of high-density lipoprotein-cholesterol and triglycerides did not change significantly. Liver enzymes did not change during treatment. There was an increase of both levels in hemoglobin (from 13.6+/-1.2 to 16.0+/-1.5 g/dl) and hematocrit (from 41+/-4 to 46+/-4) upon administration but they remained almost without exception within the physiological range. No special measures were needed. Breast and gonads/internal genitalia did not show pathological changes over the observation period.


This study reports that TU is suited for induction of virilization in FTM transsexuals without significant side effects over a longer term.

This is only an abstract. For full articles you can visit here and for PDF version you can download it here

In this picture is me and Professor Dr Louis J Gooren during our meeting in Surabaya, Indonesia. -July 30th, 2010-

He is an excellent scientist, and for more info about him you can visit here


This video shows the first one year the female to male transformation using testosterone.

Attention: I do not personally encourage you to do female to male transformation, but it is your own life. So if you decide to do the female to male transformation, you must first contact your doctor or psychiatrist and REALLY REALLY consider thoroughly about all of the consequences. This article’s purpose is just for educational and should at least improve your knowledge and risks about the transformation.

About yuan ade sukma, MD

I'm an Indonesian doctor. I Believe that science and knowledge do not belong to anyone in the world. Science and knowledge is meant to be shared to make the world a better place to live. But if you find any material posted here is violating any copyrights, feel free to contact me and I will delete that. I believe that someday my blog can change the world. I BELIEVE in the POWER of WORDS! Do you..?
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2 Responses to Safety Aspects of 36 Months of Administration of Long-acting Intramuscular Testosterone Undecanoate for Treatment of Female-to-Male Transgender Individuals

  1. Please let me know where is dr. Gooren , ı know. Him from Vrije Univ. , can you help me to contact him. dr.Tanju Cindemir, Turkey .

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