Udenafil / Zydena®, The Latest PDE5 Inhibitor, For the Treatment of Erectile Dysfunction

Udenafil / Zydena®

Udenafil has a trade name Zydena. This is one of the four famous molecules investigated for the treatment of erectile dysfunction (ED). It is well-known with proven clinical efficiency, high safety and acceptability to the patient. The unique qualities of Zydena makes it perfect choice for the user.


Zydena provides quick and strong onset of action, which lasts to twenty-four hours, high in the class of PDE-5 inhibitors, the safety profile, Zydena not have testicular toxicity. Certainly, all of these properties will be the best in its segment.

Udenafil comes in oval shaped tablets, film-coated light-pink color with light-yellow shade. There are imprinted symbol “100” on one side and symbols  “Z” and “Y” on another

1 tablet contains 100 mg udenafil;
There are one or four tablets per pack.

Udenafil pharmacological action

Zydena is drug for treatment of erectile dysfunction. Is a reversible selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5).

Udenafil enhances sexual stimulation relaxing effect of nitric oxide by inhibiting PDE-5, responsible for the breakdown of cGMP in the cavernous body. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes erections. The drug provides no effect in the absence of sexual stimulation.

Zydena greatly improves erection and the possibility of successful sexual intercourse. The action of the drug has an optimal duration – up to twenty-four hours. Effect appears after thirty minutes after taking the drug in the presence of sexual arousal.

There are no side effects on sperm quality.

Udenafil Indications

Treatment of erection disorders, characterized by the inability to achieve or maintain penile erection sufficient for satisfactory sexual intercourse.

Udenafil Dosing and Administration

Pills taken by mouth, with or without food, for 30 minutes before the alleged sexual activity.

Recommended dose – 100 mg. If necessary, taking into account individual performance and portability, the dose may be increased to 200 mg. The maximum recommended frequency of application – 1 times / day.

Side effects of Udenafil

Palpitations, prolonged erections, flushing, dizziness eye pain, increased lacrimation, nasal congestion, headache.


Sexual activity is a potential risk for patients with cardiovascular disease, hypertension, so treatment of sexual dysfunctions, including use of Zydena, should not hold for men with diseases, when sexual activity is not recommended.

Also, there is no clinical data on the use of Udenafil for patients older than 71 y.o.


  • rapid and predictable onset of action
  • provides necessary to erection hardness
  • increases the axial load on the penis
  • reduces the time of the refractory period (time after ejaculation until the next erection)
  • optimal duration of up to 24 hours
  • high safety profile in the class of PDE-5 inhibitors
  • Drinking alcohol and fatty food does not affect the action of Udenafil


Although Russian and Malaysian men have access to Zydena, countries such as the US, Europe and Canada might be in for a longer wait. Approval processes in these countries go through phases and are much more detailed and complex.

You also can check full articles below:

Efficacy and Safety of Once-Daily Dosing of Udenafil in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Chen Zhao, Sae Woong Kim, Dae Yul Yang, Je Jong Kim, Nam Cheol Park, Sung Won Lee, Jae Seung Paick, Tai Young Ahn, Kweon Sik Min, Kwangsung Park, Jong Kwan Park

Accepted 16 March 2011, Published online 25 March 2011

Also, for more information you may want to visit the reference links below:

  1. http://www.ukmedix.com
  2. http://www.ncbi.nlm.nih.gov/pubmed/16869121
  3. http://24pharma.com/index.php?productID=443
  4. http://www.edguider.com/edblog/2010/08/29/3-upcoming-ed-treatments-avanafil-zoraxel-and-zydena/
  5. http://www.chemicalbook.com/ChemicalProductProperty_EN_CB01508622.htm

About yuan ade sukma, MD

I'm an Indonesian doctor. I Believe that science and knowledge do not belong to anyone in the world. Science and knowledge is meant to be shared to make the world a better place to live. But if you find any material posted here is violating any copyrights, feel free to contact me and I will delete that. I believe that someday my blog can change the world. I BELIEVE in the POWER of WORDS! Do you..?
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12 Responses to Udenafil / Zydena®, The Latest PDE5 Inhibitor, For the Treatment of Erectile Dysfunction

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  6. al wiley says:

    PLEASE WHERE CAN I BUYo Udenafil / Zydena®,

  7. Ab Rahman Awang Damit says:

    How much it’s price in malaysia and where I can buy this product.Tq

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