Guidelines on The Management of Erectile Dysfunction, 2009

British Society for Sexual Medicine,

Guidelines on The Management of Erectile Dysfunction, 2009

Epidemiology and risk factors

Erectile dysfunction (ED) has been defined as the persistent inability to attain and/or maintain an erection sufficient for sexual performance. The risk factors for ED (sedentary lifestyle, obesity, smoking, hypercholesterolaemia and the metabolic syndrome) are very similar to the risk factors for cardiovascular disease (CVD). It is clear ED may be associated with other causes of CVD such as hypertension, dyslipidaemia and endothelial dysfunction. ED may be the first presentation of serious medical conditions such as diabetes or hypertension.

Diagnosis

Initial assessment

  • Sexual history – a detailed description of the problem, including the duration of symptoms and original precipitants, should be obtained.
  • Concurrent medical, psychiatric and surgical history should also be recorded, as should the current relationship status, history of previous sexual partners and relationships. Issues of sexual orientation and gender identity should also be noted. Finally, the patient should be asked about alcohol, smoking and illicit drug misuse.
  • The use of validated questionnaires, particularly the International Index of Erectile Function (IIEF) or the validated shorter version of the SHIM (Sexual Health Inventory for Men) may be helpful.

Physical examinations

  • All patients should have a physical examination. A genital examination is recommended, and this is essential if there is a history of: rapid onset of pain,deviation of the penis during tumescence, the symptoms of hypogonadism, other urological symptoms (past or present).
  • A digital rectal examination (DRE) of the prostate is not mandatory in ED but should be conducted in the presence of genito-urinary or protracted secondary ejaculatory symptoms.
  • Blood pressure, heart rate, waist circumference and weight should be measured.

Laboratory testing

  • The choice of investigations depends on the individual circumstances of the patient. Serum lipids and fasting plasma glucose should be measured in all patients.
  • Hypogonadism is a treatable cause of ED that may also make men less responsive, or even nonresponsive, to phosphodiesterase type 5 (PDE5) inhibitors; therefore, all men with ED should have serum testosterone measured on a blood sample taken in the morning between 08.00 and 11.00.
  • Serum prostate specific antigen (PSA) should be considered if clinically indicated. It should certainly be measured before commencing testosterone therapy and at regular intervals during testosterone therapy

Cardiovascular system

  • Coronary heart disease (CHD) is associated with many of the same risk factors as ED. Coronary artery disease (CAD) is often just one affected site in a generalised arteriopathy that is also likely to affect the arterial inflow to the corpora cavernosum of the penis
  • ED in an otherwise asymptomatic man may be a marker for underlying CAD. All men with unexplained ED should have a thorough evaluation and any risk factors for CHD that are identified should be addressed
  • A man with ED and no cardiac symptoms is a cardiac patient until proven otherwise
  • Proactive management of ED in the cardiovascular (CV) patient provides an ideal and effective opportunity to address other CV risk factors and improve treatment outcomes
  • Men with previously-diagnosed CHD should be asked about ED as part of their routine surveillance and management; ED treatments should be offered to all who desire them
  • Current NICE guidance recommends that all men with type 2 diabetes be asked annually about ED, assessed, and offered oral treatment with the medication with the lowest acquisition cost
  • There is no evidence that currently licensed treatments for ED add to the overall CV risk in patients with or without previously-diagnosed CVD
Management algorithm according to graded cardiovascular risk

Specialised investigations

Most patients do not need further investigations unless specifically indicated. However, some patients wish to know the aetiology of their ED and should be investigated appropriately. Other indications for specialist investigations include:

  • young patients who have always had difficulty in obtaining and/or sustaining an erection
  • patients with a history of trauma
  • where an abnormality of the testes or penis is found on examination
  • patients unresponsive to medical therapies that may desire surgical treatment for ED

Treatment

The primary goal of management of ED is to enable the individual or couple to enjoy a satisfactory sexual experience. This involves: identifying and treating any curable causes of ED, initiating lifestyle change and risk factor modification, providing education and counseling to patients and their partners

Reversible causes of ED

•Hormonal: hypogonadism, hyperthyroidism/hypothyroidism, hyperprolactinaemia

•Post-traumatic arteriogenic ED in young patients

•Drug-induced ED

Drugs may affect sexual response in a number of ways:

  • drugs that cause sedation may affect sexual motivation and, indirectly, cause ED
  • drugs that affect CV function, such as antihypertensive agents, may act centrally and may also affect penile haemodynamics
  • some drugs affect endocrine parameters
  • anti-androgens and oestrogens may affect both sexual desire and erection
  • drugs that cause hyperprolactinaemia, such as phenothiazines, may also affect sexual desire and erection

• Partner sexual problems

• Psychosexual counselling and therapy

• Radical prostatectomy

Lifestyle management

Lifestyle modifications can greatly reduce the risk of ED, and should accompany any specific pharmacotherapy or psychological therapy. However, pharmacotherapy should not be withheld on the basis that lifestyle changes have not been made

Lifestyle factors include:

  • psychosocial issues
  • adverse side-effects of non-prescription drugs
  • influence of any co-morbidities, including those in the partner

The potential advantages of lifestyle changes may be particularly pronounced in those with psychogenic ED, but patients with serious medical illnesses such as diabetes may also benefit from these changes, e.g. weight loss

Hypogonadism and testosterone replacement therapy

The cause of hypogonadism should always be sought before treatment with testosterone is initiated, but this does not mean that treatment for ED should be deferred. Prior assessment and safety monitoring should be performed according to contemporary authoritative guidelines

Men with a total serum testosterone that is consistently <12 nmol/l might benefit from up to a 6 months trial of testosterone replacement therapy for ED and should be managed according to current guidelines (see algorithm below)

 

Algorithm for androgen therapy in a man presenting with ED

A range of well-tolerated testosterone formulations is available including long-acting (three-monthly) testosterone injection or daily application of a transdermal testosterone gel are acceptable to most men.

First-line treatment

PDE5 inhibitors (e.g. sildenafil, tadalafil, vardenafil):

  • have proven efficacy and safety both in non-selected populations of men with ED and in specific sub-groups of patients (e.g, men with diabetes and those who have had a prostatectomy)
  • sildenafil and vardenafil are relatively short-acting drugs, having a half life of approximately 4 hours, whereas tadalafil has a significantly longer half life of 17.5 hours
  • are not initiators of erection but require sexual stimulation in order to facilitate an erection. It is currently recommended that patients should receive eight doses of a PDE5 inhibitor with sexual stimulation at maximum dose before classifying a patient as a non-responder
  • tadalafil is licensed for daily use at 2.5 mg and 5 mg for PDE5 responders who anticipate sexual activity more than twice per week. This regime may be more cost effective in such cases and clinical trials suggest a marked reduction in reported adverse events

• Vacuum erection devices:

  • are highly effective in inducing erections regardless of the aetiology of the ED
  •  reported satisfaction rates vary considerably from 35% to 84%
  • long-term usage of vacuum devices also varies but is considerably higher than for self-injection therapy
  • most men who are satisfied with vacuum devices continue to use them long term
  • adverse effects include bruising, local pain, and failure to ejaculate. Partners sometimes report the penis feels cold
  • serious adverse events are very rare but skin necrosis has been reported

Second-line treatment

  • Intracavernous injection therapy
  • Intraurethral alprostadil

Third-line treatment

• Penile prosthesis

  • should be offered to all patients who are unwilling to consider, failing to respond to, or unable to continue with medical therapy or external devices. All patients and their partners should be counselled pre-operatively, see and handle all the available devices and, if possible, speak to other patients who have had surgery
  • particularly suitable for those with severe organic ED, especially if the cause is Peyronie’s disease or post priapism. All patients should be given a choice of either a malleable or inflatable prosthesis

Full guideline available from…
British Society for Sexual Medicine, Holly Cottage, Fisherwick, Near Lichfield, Staffordshire WS14 9JL (% – 01543 432622)
http://www.bssm.org.uk

British Society for Sexual Medicine. Guidelines on the management of erectile dysfunction July 2009.

Sources:

About yuan ade sukma, MD

I'm an Indonesian doctor. I Believe that science and knowledge do not belong to anyone in the world. Science and knowledge is meant to be shared to make the world a better place to live. But if you find any material posted here is violating any copyrights, feel free to contact me and I will delete that. I believe that someday my blog can change the world. I BELIEVE in the POWER of WORDS! Do you..?
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2 Responses to Guidelines on The Management of Erectile Dysfunction, 2009

  1. Pingback: Erectile Dysfunction Video, The Causes, and The Treatments | Yuan Ade Sukma's Blog

  2. Victor says:

    Erection dysfunction has lengthy been considered to be probably the most troublesomely typical male intimate circumstances. There are huge numbers who experience from it and regrettably enough with insufficient zero aftereffect drugs the pursuit for a solution is becoming even more complicated.

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